Line your air fryer basket loosely with foil.
In a large, clean bowl, mix together the Panko bread crumbs, milk, mayonnaise, Worcestershire, onion, parsley, salt, garlic powder, paprika and pepper.
Break up the ground beef into small pieces over the breadcrumb mixture.
Mix with your hands or a spatula until the Panko breadcrumb mixture is well blended into the beef.
Form the mixture into a meatloaf shape, on the parchment paper.
Transfer the meatloaf on the parchment paper to the air fryer basket lined with foil.
Air fry at 350 degrees F for 30-35 minutes. Check the internal temperature of the meatloaf. It should be at about 150 degrees F.
While the meatloaf is cooking in the air fryer, stir together the ketchup, lemon juice and brown sugar until blended.
Use a pastry brush or spoon to spread the ketchup glaze over the almost fully cooked meatloaf.
Air fry the meatloaf with the glaze at 400 degrees F for 5 minutes.
Check to make sure the internal temperature of the meatloaf is 160 degrees F.
Allow the meatloaf to rest for about 5 minutes before slicing it to serve.